![]() Department of Health and Human Services (HHS). Federal drug testing cutoff levelsĬutoff levels for federally-regulated drug testing programs are established based on mandatory guidelines set by U.S. While that may be the case, other possible interpretations are that a drug was present below the cutoff or the testing panel did not include the drug the individual was using. Consequently, a negative drug test does not necessarily mean that no drug is present. Only when a drug or drug metabolite is identified at a concentration equal to or above the administrative cutoff is a specimen reported by the laboratory as positive. It is important to select a specimen type and cutoff level based on the desired window of detection and any regulatory requirements. What does ng/mL and pg/mg mean on your drug screen?Ĭutoff levels are expressed in nanograms (ng) per milliliter (mL) for urine and oral fluid testing or picograms (pg) per milligram (mg) for hair testing. ![]() The confirmatory test uses definitive methods, such as chromatography-mass spectrometry (e.g., GC-MS, LC-MS/MS), that specifically identify and quantify the drug/metabolite in the specimen. The initial test is designed to separate negative specimens from further consideration. In workplace drug testing, the industry standard process involves two-tiered testing – an initial screen on one portion of the specimen, followed by a confirmatory test on a second portion of the original specimen. Drug testing detects the presence of drugs and drug metabolites using cutoff levels to determine whether a specimen tests positive or negative for the use of a specific drug.
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